Hemiepifisiodesis femoral distal mediante biomateriales reabsorbibles: Estudio experimental en el conejo

Se valoró experimentalmente un implante triangular compuesto de 3 tornillos metálicos unidos por un filamento de PDS II o Tendofil como método de epifisiodesis. Se utilizaron conejos esqueléticamente inmaduros, divididos en 4 Grupos, según el seguimiento postoperatorio (1,2,3 y 4 meses), subdivididos a su vez en 2 subgrupos según el filamento empleado. Se colocó el implante en la cara lateral de la epífisis femoral distal izquierda. La extremidad posterior derecha sirvió como control practicándose estudios radiológicos, histológicos e histomorfométrico. Las extremidades intervenidas presentaron una desviación en valgo significativa respecto a las control. El implante utilizado consiguió el frenado misario con ambos filamentos. Durante el primer mes, la eficacia del implante reabsorbible fue comparable al metálico. Posteriormente, el metálico resultó más eficaz. Los estudios histológicos e histomorfométrico mostraron un frenado asimétrico de la fisis intervenida. No hubo daños fisarios en relación con la degradación del implante reabsorbible. Nuestros resultados sugieron el diseño de implantes reabsorbibles en la cirugía del cartílago de crecimiento.A triangular implant compound by 3 metallic screws united by a filament (PDS II vs. Tendofil) as method of experimental epiphysiodesis was evaluated. They were used 32 immature rabbits, divided into 4 Groups acoording to the follow-up (1.2.3. and 4 months), and subdivided according to the employed filament. The implant was located at the lateral face of the distal left femoral epiphysis. The right extremity served as control. Radiographic, histologic and histomorphometric studies were performed. The operated legs presented a significant valgus deviation as compared to controls. The epiphysiodesis was achieved with both types of filaments. During the first month, the efficiency of the absorbable implant was comparable to the metallic. Thereafter, the metallic implant results more effective. Histologic and morphometric studies showed the hemiepiphysiodesis. No physeal damaged in relationship to the degradation of the absorbable implant was observed. Our results suggests the use of absorbable implant in growth plate surgery

Feasibility study of Pb-Pollutant detection in soils by step-heating thermography

RESUMEN: Este trabajo presenta un estudio de viabilidad en la detección de contaminantes en suelos mediante el empleo de técnicas de medida por termografía infrarroja activa. Este estudio propone un método alternativo a las técnicas actuales de detección e identificación de suelos contaminados mediante ensayos no destructivos que permitan reducir los costes y tiempo de ejecución necesario para la detección de los contaminantes. Para ello, se ha empleado como técnica de medida la termografía de pulso largo. Partiendo de los modelos térmicos establecidos para el análisis de suelos se aplican diversos métodos de preprocesado a las secuencias termográficas obtenidas para caracterizar la respuesta térmica del suelo. A partir de estos datos se emplean redes neuronales artificiales (ANN- Artificial Neural Networks) como herramienta de análisis que permita discernir la presencia o no de contaminantes.ABSTRACT: A feasibility study of the detection of pollutants in soil with thermographic measurement techniques is presented in this paper. This study proposes an alternative method to current techniques for detection and identification of contaminated soils by non-destructive testing to reduce costs and the required execution time. For this purpose, step-heating thermography is used as measurement technique. Taking into account the soil thermal models, different pre-processing methods are applied to the captured thermogram sequences to characterize the soil thermal response data; and Artificial Neural Networks (ANN) are used as a processing tool to discern the presence or absence of contaminants in soil

Estado actual de la prevención de los accidentes de montaña en Aragón

The number of mountain rescues, as the number of injured mountaineering, they keep growing in Spain, and in Aragon where they take place nearly 40 % of the rescues. However, the rescued mountaineering only are the top of the iceberg of the mountain assistance; mountaineering who suffer an accident but do not call any mountain rescue services consume economic resources too. Mountain accidents are a problem of Public Health, therefore it is necessary to know the current situation of mountain accident prevention in Aragon. The aims of this study were: To analyze the real requirements for the balance between need, offer and demand, for the suitable application of the resources. To establish the requirements of the implied groups (users, professionals and institutions) to reduce the effect and severity of the mountain accidents. We have used the results of the institutional campaigns Montañas para Vivirlas Seguro 2000, 2001 and 2002, the occupations related to the sports mountain activities have been analyzed and we have directly consulted with the implied institutions. Mountain knowledge and information of the mountain users in Aragon are not adapted to the potential risk of the mountain activities; whereas there is demonstrated the need to rule some mountain professions. The mountain rescue is effective and efficient; the medical assistance is effective, but not efficient (attending to the criteria of need, offer and demand) and the prevention is neither effective nor efficient. Therefore, it is necessary the development and implementation of a mountain injury registry, as well as a center that coordinates the research work on mountain accident prevention as a basis for the design of strategies aimed at informing, educating and training people interested in mountain sports.El número de rescates en montaña, al igual que el número de heridos, sigue una línea ascendente en España y en Aragón, que es donde se ubican cerca del 40% del total de los rescates. Sin embargo, los montañeros rescatados sólo son la punta del iceberg de la asistencia que se dedica a los accidentes de montaña; los accidentados que no solicitan rescate también consumen recursos económicos. Partiendo de la base de que los accidentes de montaña son un claro problema de Salud Pública, es necesario conocer el estado actual de la prevención de los accidentes de montaña en Aragón, con los objetivos de: Analizar las necesidades reales para buscar el equilibrio entre necesidad, oferta y demanda, a partir de la adecuada utilización de los recursos. Establecer las necesidades de los colectivos implicados (usuarios, profesionales e instituciones) para reducir la incidencia y severidad de los accidentes de montaña. Para ello, hemos utilizado los resultados de las campañas institucionales Montañas para Vivirlas Seguro de los años 2000, 2001 y 2002, se han analizado las ocupaciones relacionadas con las actividades deportivas en la montaña y hemos consultado directamente con las instituciones implicadas. El nivel de formación e información del usuario de la montaña en Aragón no es el adecuado para el riesgo potencial de las actividades de montaña; mientras que se evidencia la necesidad de reglar algunas profesiones de la montaña. El rescate en montaña es efectivo, eficaz y eficiente; la medicalización es efectiva, eficaz y no eficiente (atendiendo a los criterios de necesidad, oferta y demanda) y la prevención ¿a pesar de los esfuerzos- es no eficaz, no eficiente y no efectiva. Por todo ello, es urgente la creación de un servicio de vigilancia de los accidentes de montaña, así como un centro que coordine las propuestas y actuaciones orientadas a prevenir los accidentes de montaña

Estado actual de la prevención de los accidentes de montaña en Aragón

The number of mountain rescues, as the number of injured mountaineering, they keep growing in Spain, and in Aragon where they take place nearly 40 % of the rescues. However, the rescued mountaineering only are the top of the iceberg of the mountain assistance; mountaineering who suffer an accident but do not call any mountain rescue services consume economic resources too. Mountain accidents are a problem of Public Health, therefore it is necessary to know the current situation of mountain accident prevention in Aragon. The aims of this study were: To analyze the real requirements for the balance between need, offer and demand, for the suitable application of the resources. To establish the requirements of the implied groups (users, professionals and institutions) to reduce the effect and severity of the mountain accidents. We have used the results of the institutional campaigns Montañas para Vivirlas Seguro 2000, 2001 and 2002, the occupations related to the sports mountain activities have been analyzed and we have directly consulted with the implied institutions. Mountain knowledge and information of the mountain users in Aragon are not adapted to the potential risk of the mountain activities; whereas there is demonstrated the need to rule some mountain professions. The mountain rescue is effective and efficient; the medical assistance is effective, but not efficient (attending to the criteria of need, offer and demand) and the prevention is neither effective nor efficient. Therefore, it is necessary the development and implementation of a mountain injury registry, as well as a center that coordinates the research work on mountain accident prevention as a basis for the design of strategies aimed at informing, educating and training people interested in mountain sports.El número de rescates en montaña, al igual que el número de heridos, sigue una línea ascendente en España y en Aragón, que es donde se ubican cerca del 40% del total de los rescates. Sin embargo, los montañeros rescatados sólo son la punta del iceberg de la asistencia que se dedica a los accidentes de montaña; los accidentados que no solicitan rescate también consumen recursos económicos. Partiendo de la base de que los accidentes de montaña son un claro problema de Salud Pública, es necesario conocer el estado actual de la prevención de los accidentes de montaña en Aragón, con los objetivos de: Analizar las necesidades reales para buscar el equilibrio entre necesidad, oferta y demanda, a partir de la adecuada utilización de los recursos. Establecer las necesidades de los colectivos implicados (usuarios, profesionales e instituciones) para reducir la incidencia y severidad de los accidentes de montaña. Para ello, hemos utilizado los resultados de las campañas institucionales Montañas para Vivirlas Seguro de los años 2000, 2001 y 2002, se han analizado las ocupaciones relacionadas con las actividades deportivas en la montaña y hemos consultado directamente con las instituciones implicadas. El nivel de formación e información del usuario de la montaña en Aragón no es el adecuado para el riesgo potencial de las actividades de montaña; mientras que se evidencia la necesidad de reglar algunas profesiones de la montaña. El rescate en montaña es efectivo, eficaz y eficiente; la medicalización es efectiva, eficaz y no eficiente (atendiendo a los criterios de necesidad, oferta y demanda) y la prevención ¿a pesar de los esfuerzos- es no eficaz, no eficiente y no efectiva. Por todo ello, es urgente la creación de un servicio de vigilancia de los accidentes de montaña, así como un centro que coordine las propuestas y actuaciones orientadas a prevenir los accidentes de montaña

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old